XTra™ DNA Residual DNA Detection Kit

XTra™ DNA Residual DNA Detection Kit

$2,048.00

Sensitive and rapid real-time PCR kit for quantification of residual host cell genomic DNA in biopharmaceutical products, ensuring product safety.

Purchase this item and get 204 Points
Purchase this item and get 204 Points
Product Description

The XTra™ DNA Residual DNA Detection Kit represents the pinnacle of innovation in pharmaceutical product testing, offering a comprehensive solution for the precise quantification of residual host cell genomic DNA (gDNA). In the intricate landscape of biopharmaceutical production, ensuring the purity and safety of therapeutic materials is paramount. Contaminating substances, particularly residual DNA from host cells, present inherent risks to product efficacy and patient safety. The XTra™ DNA Residual DNA Detection Kit emerges as a robust and indispensable tool in the arsenal of biopharmaceutical quality control, empowering researchers and industry professionals to mitigate these risks with unparalleled accuracy and efficiency.

At its core, the XTra™ DNA Residual DNA Detection Kit leverages advanced molecular biology techniques, including dual-labeled hydrolysis probes, to achieve sensitive and rapid real-time PCR quantification of residual DNA. This cutting-edge approach enables precise measurement of residual host cell DNA levels, even at remarkably low concentrations, ensuring the stringent safety standards required for biopharmaceutical products. The kit is meticulously designed to deliver consistent and reliable results, offering exceptional reproducibility and a high linear range across a spectrum of experimental conditions.

Central to the functionality of the XTra™ DNA Residual DNA Detection Kit is its capacity to accurately quantify residual DNA while minimizing false positives and negatives. The kit incorporates a suite of controls, including the XTra™ DNA Internal Control and the XTra™ DNA Residual DNA Positive Control, which serve as essential benchmarks for assay performance and reliability. These controls not only validate the integrity of the assay but also provide critical insights into potential inhibitors and experimental variables, enhancing confidence in assay outcomes.

Moreover, the XTra™ DNA Residual DNA Detection Kit is engineered for versatility and compatibility, seamlessly integrating into existing laboratory workflows and instrumentation. Whether deployed in academic research settings or industrial laboratories, the kit exhibits exceptional adaptability, accommodating a wide range of real-time PCR cyclers and experimental protocols. This flexibility ensures accessibility and usability across diverse laboratory environments, empowering researchers to leverage the kit’s capabilities with ease and efficiency.

In essence, the XTra™ DNA Residual DNA Detection Kit represents a transformative advancement in biopharmaceutical quality assurance, offering unparalleled sensitivity, reliability, and efficiency in the detection and quantification of residual host cell genomic DNA. By safeguarding the purity and integrity of therapeutic materials, this innovative kit plays a pivotal role in upholding the highest standards of product safety and efficacy in the dynamic landscape of biopharmaceutical research and development.

Kit Contents

●  XTra™ DNA Residual DNA PCR MasterMix (1 X 1.25 mL)
●  XTra™ DNA Internal Control DNA and Assay
●  CHO DNA Positive control and CHO-Assay
●  Uracil-N-Glycosylase (1 X 0.1mL)
●  High-ROX Dye Solution (1 X 0.21 mL)
●  ROX Dye Solution (1X 0.21 mL)
●  Nucleic Acid Dilution Buffer
●  TE Buffer

Technical Parameters

●  RNA input: 25 ng to 5 μg per reaction
●  Compatible with a wide range of real-time cyclers, including those from QIAGEN, Applied Biosystems, Bio-Rad, Roche, and Agilent
●  Low limit of quantification with excellent reproducibility
●  High linear range
● Synthesized cDNA is immediately ready for use in downstream applications

Applications

●  Quantification of residual host cell genomic DNA in pharmaceutical product testing
●  Ensuring product safety by detecting contaminating substances
●  Suitable for use on a wide range of real-time cyclers in various laboratory settings
●  Compatible with assays requiring high sensitivity and reliability, such as CHO Detection Kit for residual Chinese Hamster Ovary (CHO) cell DNA

Product FAQs
What is the limit of quantification of this kit?

The XTra™ DNA Residual DNA Detection Kit offers a low limit of quantification with excellent reproducibility, ensuring reliable detection even at low levels of residual DNA.

Can this kit be used with other gene expression analysis assays?

While primarily designed for quantifying residual host cell genomic DNA, this kit can potentially be adapted for use with other gene expression analysis assays, depending on specific experimental requirements.

What controls are included in the kit?

The kit includes the XTra™ DNA Internal Control and the XTra™ DNA Residual DNA Positive Control to ensure reliable detection and assay functionality, providing confidence in assay results.

Is this kit compatible with different real-time cyclers?

Yes, the XTra™ DNA Residual DNA Detection Kit is compatible with a wide range of real-time cyclers, allowing for sensitive and reliable detection across various instruments commonly found in laboratory settings.

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